The scientific sessions will take place in Lisbon and will be live-streamed to the Virtual platform for on-line attendees.
Please be aware that all times in the scientific program are in WEST, UTC+1 (Lisbon, Portugal)
We invite you to browse the Final Program below
You can download the printable program here
Thursday, 28th September
09.00 – 12.00
Introductory Session for young EWOG
12h00 – 12.45
Registration for the Symposium
12.45
Welcome to the Symposium
Paula Kjöllerström – Chair of the Local Committee
Pierre Goncalves – Local Committee
Charlotte Niemeyer – Chair of EWOG-MDS
Brigitte Strahm – Chair of EWOG-SAA
13.00 SESSION I
SEVERE APLASTIC ANEMIA
Chairs: Ayami Yoshimi, Nuno Reis Farinha
13.00 – 13.30
Recent advances and long-term results of medical treatment of Acquired Aplastic Anemia
Phillip Scheinberg (São Paulo, Brazil)
13.30 – 14.00
THE ROLE OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN APLASTIC ANEMIA (OC1)
Brigitte Strahm (Freiburg, Germany)
14.00 – 14.15
Accelerated clearance of anti-thymocyte globulin in children transplanted for refractory cytopenia of childhood versus aplastic anemia is associated with increased risk of GvHD (OC2)
Eva Koopman-Coenen*; Joyce Meesters-Ensing; Stefan Nierkens; Ireen Kal; Konradin Müskens; Birgitta Versluys; Caroline Lindemans; Marc Bierings; Rick Admiraal; Mirjam Belderbos
*Utrecht, The Netherlands
14.15 – 14.30
Variable clinical courses of varicella zoster virus infection – or vaccination-related bone marrow failure (OC3)
Vasil Toskov*; Annamaria Cseh; Alexander Claviez; Natalia Rotari; Beatrice Drextler; Stephan Schwarz-Furlan; Matthias Braun; Peter Bader; Peter Lang; Rita Beier; Bernhard Erdlenbruch; Monika Führer; Miriam Erlacher; Charlotte M Niemeyer; Brigitte Strahm; Ayami Yoshimi
*Freiburg, Germany
14.30 – 15.00
Somatic mutations and dynamics of clonal hematopoiesis in Acquired Aplastic Anemia
Austin Kulasekararaj (London, UK)
15.00 – 15.15
Next Generation Sequencing approach to Bone Marrow Failure Syndromes – Portuguese experience (OC4)
Margarida Coucelo*; Joana Azevedo; Isabel Bogalho; Ana Teresa Simões; Ana Catarina Oliveira; Sara Batalha; Conceição Constanço; Teresa Melo; José Carlos Almeida; Joana Desterro; Patrícia Ribeiro; Emília Costa; Anabela Ferrão; Paula Kjollerstrom; Catarina Geraldes
*Coimbra, Portugal
15.15 – 15.30
COFFEE BREAK
15.30 SESSION II
JUVENILE MYELOMONOCYTIC LEUKEMIA (I)
Chairs: Tim Lammens, Valerie de Haas
15.30 – 16.00
Novel approaches targeting the RAS pathway in JMML (OC5)
Eliot Stieglitz (San Francisco, USA)
16.00 – 16.15
The interface of epigenetics and energy metabolism in juvenile myelomonocytic leukemia (OC6)
Zoé Wehbe*; Ruba Hammad; Toni Cathomen; Sheila Bohler; Jovana Rajak; Miriam Erlacher; Foued Ghanjati; Charlotte Niemeyer; Christian Flotho
*Freiburg, Germany
16.15 – 16.45
Clonal architecture in JMML (OC7)
Christian Flotho (Freiburg, Germany)
16.45 – 17.00
Genomic landscape and single base substitution mutational signatures in juvenile myelomonocytic leukemia: a new JMML portrait (OC8)
Alberto Peloso*; Andrea Binatti; Alice Cani; Concetta Micalizzi; Simone Cesaro; Laura Sainati; Franco Locatelli; Stefania Bortoluzzi; Riccardo Masetti; Silvia Bresolin
*Padua, Italy
17.00 – 17.15
Homozygous CBL mutation in B lymphocytes after CBL-driven JMML impairs B cell maturation, function and antibacterial immunity (OC9)
Jonathan Bohlen*; Marine Michelet; Federica Barzaghi; Francesco Saettini; Francesca Vendemini; Albert Catala; Laia Alsina; Francesca Conti; Fillippo Consonni; Davide Learndini; Riccardo Masetti; Edoardo Muratore; Francesco Baccelli; Ivan Bagaric; Taja Vatovec; Feroj Seyed; Isabelle Andre; Lori Buetow; Eric Delabesse; Laetitia Largeaud; Cindy Ma; Laurent Abel; Steicy Sobrino; Masato Ogishi; Boris Bessot; Cecile Rouillon; Christine Bole; Yoann Seeleuthner; Tom Le Voyer; Darawan Rinchai; Jeremie Rosain; Peng Zhang; Matthieu Chaldebas; Anna-Lena Neehus; Lucia Erazo; Zarah Janda; Camille Soudee; Chantal Lagrese; Emmanuelle Six; Danny Huang; Stuart Tangye; Vivien Beziat; Eleonora Gambineri; Marinella Veltroni; Miriam Erlacher; Alessandro Aiuti; Marlene Pasquet; Jean-Laurent Casanova; Jacinta Bustamante
*New York, USA
17.15 – 17.30
BCR:ABL-NEGATIVE MYELOPROLIFERATIVE NEOPLASMS IN CHILDREN AND ADOLESCENTS: INCREASED DISEASE BURDEN IN PATIENTS WITH JAK2 MUTATION, UNMET DIAGNOSTIC NEEDS AND OPTIMAL TREATMENT OPTIONS (OC10)
Charikleia Kelaidi*; Kondylia Antoniadi; Loizos Petrikkos; Vassilios Papadakis; Maria Ampatzidou; Maria Kourti; Vasiliki Tzotzola; Aikaterini Bountali; Kalliopi Manola; Kalliopi Stefanaki; Sophia Polychronopoulou *Athens, Greece
17:30 – 18.00
Official opening of the symposium
Nuno Reis Farinha – President of the Portuguese Society of Hematology and Oncology
Paula Kjöllerström – Chair of the Local Committee
Charlotte Niemeyer – Chair of EWOG-MDS
Brigitte Strahm – Chair of EWOG-SAA
Friday, 29th September
08.30 – 09.30
Young EWOG welcome breakfast
08.00 SESSION III
JSPHO-EWOG SPEED SESSION AND SELECTED POSTERS
Chairs: Brigitte Strahm, Yoshiyuki Takahashi
08.00 – 08.30
Methylation, SETBP1/JAK3, and CBL
Manabu Wakamutsu (Nagoya, Japan)
08.30 – 09.00
Predisposition in JMML
Christian Flotho (Freiburg, Germany)
09.00 – 09.30
Selected Posters
09.30 SESSION IV
JUVENILE MYELOMONOCYTIC LEUKEMIA (II)
Chairs: Albert Catala, Jean-Pierre Gonçalves
09.30 – 09.45
SH2B3 germline mutation cause a multisystem disorder with predisposition to myeloproliferative neoplasms (OC11)
Davide Leardini*; Sara Cerasi; Francesco Baccelli; Francesca Gottardi; Edoardo Muratore; Krisztián Miklós Kállay; Paula Kjollerstrom; Sara Batalha; Elisa Rumi; Valeria Santini; Marco Gabriele Raddi; Anupama Rao; Ana Rio-Machin; Riccardo Masetti
*Bologna, Italy
09.45 – 10.00
Early relapse detection in JMML patients following haematopoietic stem cell transplant (OC12)
Susanne Kricke*; Anupama Rao; Eleni Louka; Katharine Patrick; Stuart Adams; Owen Williams; Elaine Cloutman-Green
*London, UK
10.00 – 10.15
How to design the next clinical study in JMML? (O11)
Charlotte Niemeyer (Freiburg, Germany)
10.15 – 10.30
Coffee Break
10.30 – 11.30
Poster session I with Poster Walk (see list of the posters)
11.30 SESSION V
PATHOPHYSIOLOGY OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA
Chairs: Martina Rudelius, Charlotte Niemeyer
10.30 – 11.50
Implications of novel classification of myeloid neoplasms for childhood MDS (OC14)
Katherine R. Calvo (Bethesda, USA)
11.50 – 12.10
What can we deduce from genetic classification of myeloid neoplasia for therapy in pediatrics? (OC15)
Henrik Hasle (Aarhus, Denmark)
12.10 – 12.30
Discussion
12.30 – 12.45
The new kid on the block: UBTF-TD (OC16)
Miriam Erlacher (Freiburg, Germany)
12.45 – 13.00
Impact of prognosis of cytogenetic alterations in Brazilian children with myelodysplastic neoplasm (OC17)
Viviane Lovatel*; Eliane Rodrigues; Beatriz Da Silva; Rita De Cássia Tavares; Amanda Fonte; Ana Paula Bueno; Teresa Fernandez
*Rio de Janeiro, Brazil
13.00 – 13.30
Lunch
13.30 – 14.30
Poster session II with Poster Walk
(see list of the posters below)
14.30 SESSION VI
BONE MARROW FAILURE AND OTHER GERMLINE PREDISPOSITION
Chairs: Valeria Santini, Petr Sedlacek
14.30 – 15.00
Clonal hematopoiesis in Shwachman-Diamond syndrome: mechanism and clinical implications (OC18)
Akiko Shimamura (Boston,USA)
15.00 – 15.15
Functional analyses of RUNX1 variants in the context of familial platelet disorder with predisposition to hematologic malignancies (OC19)
Melanie Decker*; Förster Alisa; Prüne Alina; Anne Seebacher; Alena Wittstock; Thomas Illig; Brigitte Schlegelberger; Tim Ripperger
*Hannover, Germany
15.15 – 15.30
Genotype/phenotype associations in 174 individuals with germline GATA2 mutations (OC20)
Lili Kotmayer*; Emilia Kozyra; Maximilian Kaiser; Michael Dworzak; Barbara De Moerloose; Jan Starý; Henrik Hasle; Kirsi Jahnukainen; Sophia Polychronopoulou; Krisztián Kállay; Owen Smith; Shlomit Barzilai; Riccardo Masetti; Jochen Buechner; Marek Ussowicz; Paula Kjollerstrom; Ivana Boďová; Marko Kavcic; Albert Catala; Dominik Turkiewicz; Markus Schmugge; Valérie De Haas; Rebecca Voss; Anna Bigas; Damia Romero; Csaba Bödör; Miriam Erlacher; Alessandra Giorgetti; Charlotte Niemeyer; Marcin Wlodarski
*Budapest, Hungary
15.30 – 15.45
Loss of HSC stemness identity is associated with exhaustion and hyporesponsiveness in GATA2 deficiency syndrome (OC21)
Laëtitia Largeaud*; Vincent Fregona; Laura Jamrog; Camille Hamelle; Stephanie Dufrechou; Naïs Prade; Esmaa Sellam; Pauline Enfedaque; Manon Bayet; Sylvie Hebrard; Christine Didier; Eric Delabesse; Bastien Gerby; Marlène Pasquet; Cyril Broccardo
*Toulouse, France
15.45 – 16.00
Germline loss-of-function mutations in MDM4 cause a new bone marrow failure syndrome with tp53-dependent hematopoietic cell death (OC22)
Richa Sharma*; Senthil Velan Bhoopalan; Robert Meyer; Lei Han; Shondra M. Pruett-Miller; Claudia Khurana; Miriam Erlacher; Jean Soulier; Fabian Beier; Marcin Wlodarski
*Memphis, USA
16.00 – 16.15
Coffee Break
16.15 SESSION VI
BONE MARROW FAILURE AND OTHER GERMLINE PREDISPOSITION (continued)
Chairs: Hannah Tamary, Kristián Kállay
16.15 – 16.45
Genome sequencing approaches for diagnosis and discovery of BMF/MDS specific genetic alterations (OC23)
Marcin Wlodarski (Memphis, USA)
16.45 – 17.00
Myelodysplastic syndrome and leukemia is a secondary event after bone marrow failure in Gata2 haploinsufficient mice (OC24)
Cansu Koyunlar; Juncal Fernandez-Orth; Julia Weiss; Emanuele Gioacchino; Hans De Looper; Geoffrey Andrieux; Mariette Ter Borg; Baris Yigit; Joke Zink; Remco Hoogenboezem; Irene Gonzalez-Mendez; Eric Bindels; Mathijs Sanders; Ivo Touw; Miriam Erlacher; Emma De Pater*
*Rotterdam, The Netherlands
17.00 – 17.15
Optical genome mapping: a new tool to overcome conventional cytogenetics’ limitations in patients with bone marrow failure (OC25)
Josune Zubicaray*; Ana Gomez; June Iriondo; Reyes Gimenez; Lorea Abad; Carmen Matasans; Elena Sebastian; Alejandro Sanz; Jesus Gonzalez De Pablo; Manuel Ramirez; Julian Sevilla
*Madrid, Spain
17.15 – 17.30
A countrywide study of GATA2 deficiency in Italy reveals novel symptoms and genotype-phenotype correlation (OC26)
Samuele Roncareggi*; Katia Girardi; Francesca Fioredda; Lucia Pedace; Luca Arcuri; Raffaele Badolato; Sonia Bonanomi; Erika Borlenghi; Emilia Cirillo; Tiziana Coliva; Filippo Consonni; Francesca Conti; Piero Farruggia; Eleonora Gambineri; Fabiola Guerra; Gaia Mancuso; Antonio Marzollo; Riccardo Masetti; Concetta Micalizzi; Daniela Onofrillo; Claudio Pignata; Valeria Santini; Francesca Vendemini; Andrea Biondi; Francesco Saettini
*Monza, Italy
17.30 – 17.45
CHEK2 germline variants and allogeneic hematopoietic stem cell transplant outcomes (OC27)
Atte K Lahtinen; Jessica Koski; Jarmo Ritari; Kati Hyvärinen; Satu Koskela; Jukka Partanen; Kim Vettenranta; Minna Koskenvuo; Riitta Niittyvuopio; Urpu Salmenniemi; Maija Itälä-Remes; Kirsi Jahnukainen; Outi Kilpivaara; Ulla Wartiovaara-Kautto; Maarja Karu*
*Helsinki, Finland
Saturday, 30th September
09:00 SESSION VII
INNOVATIVE THERAPIES IN MYELODYSPLASTIC SYNDROME, ACUTE MYELOID LEUKEMIA AND JUVENILE MYELOMONOCYTIC LEUKEMIA
Chairs: Anupama Rao, Henrik Hasle
09.00 – 09.30
Novel approaches of immune and cellular therapies for high risk pediatric myeloid malignancies
Franco Locatelli (Rome, Italy)
09.30 – 09.45
Pediatric MDS in GATA2-Deficiency: Enhanced Histone Trimethylation and Deregulated Apoptosis as Driver? (OC28)
Franziska Schreiber*; Guido Piontek; Yuki Schneider-Kimoto; Stephan Schwarz-Furlan; Rita De Vito; Franco Locatelli; Carole Gengler; Charlotte M. Niemeyer; Miriam Erlacher; Martina Rudelius
*Munich, Germany
09.45 – 10.00
Venetoclax-based therapies in pediatric advanced MDS and relapsed /refractory AML: a multicenter retrospective analysis (OC29)
Riccardo Masetti*; Francesco Baccelli; Davide Leardini; Francesca Gottardi; Francesca Vendemini; Alessandro Digangi; Marco Becilli; Mariachiara Lodi; Manuela Tumino; Luca Vinci; Miriam Erlacher; Brigitte Strahm; Charlotte M. Niemeyer; Franco Locatelli
*Bologna, Italy
10.00 – 10.15
Juvenile myelomonocytic leukemia (JMML) cells escape immune surveillance by multiple mechanisms (OC30)
Jun Wang*; Jovana Rajak; Naile Koleci; Hui Xiao; Anton Niels Wehner; Bertram Bengsch; Juncal Fernandez-Orth; Charlotte Niemeyer; Sheila Bohler; Miriam Erlacher
*Freiburg, Germany
10.15 – 10.30
COFFEE BREAK
10.30 SESSION VII
INNOVATIVE THERAPIES IN MYELODYSPLASTIC SYNDROME, ACUTE MYELOID LEUKEMIA AND JUVENILE MYELOMONOCYTIC LEUKEMIA (continued)
Chairs: Anupama Rao, Henrik Hasle
10.30 – 11.00
Pathway-directed therapy approach in pediatric MDS and AML (OC31)
Barbara De Moerloose, Ghent, Belgium
11.00 – 11.15
Development of new gene editing approaches for bone marrow failure and MDS predisposition syndromes (OC32)
Damian Krzyzanowski*; Mjad Khiami; Lei Han; Sushree Sahoo; Shondra Miller; Shengdar Tsai; Senthil Bhoopalan; Jonathan Yen; Marcin Wlodarski
*Memphis, USA
11.15 – 11.30
ILLUSTRATION OF CLONAL ARCHITECTURE IN JUVENILE MYELOMONOCYTIC LEUKEMIA BY TARGETED SINGLE-CELL DNA SEQUENCING (OC33)
Foued Ghanjati*; Miriam Erlacher; Dirk Lebrecht; Peter Nöllke; Franco Locatelli; European Working Group Of Myelodysplastic Syndromes In Childhood; Charlotte Niemeyer; Christian Flotho
*Freiburg, Germany
11.30 – 11.45
Onco-Fetal Reprogramming Drives High-Risk Juvenile Myelomonocytic Leukemia, which can be Targeted by Anti-CD52 Treatment (OC34)
Mark Hartmann; Maximilian Schönung; Jovana Rajak; Joschka Hey; Valentin Maurer; Ling Hai; Sina Staeble; Jens Langstein; Katharina Bauer; Mariam Hakobyan; Laura Jardine; Sheila Bohler; Dominik Vonficht; Abdul-Habib Maag; Dirk Lebrecht; Katrin M. Bernt; Roland Roelz; Tobias Boch; Eleonora Khabirova; Pavlo Lutsik; Simon Haas; Muzlifah Haniffa; Sam Behjati; Jan-Philipp Mallm; Christian Buske; Michael D. Milsom; Stefan Fröhling; Marc-Jan Bonder; Charlotte Niemeyer; Christian Flotho; Christoph Plass; Miriam Erlacher; Matthias Schlesner; Daniel B. Lipka*
*Heidelberg, Germany
11.45 – 12.45
Closing remarks and presentation of poster prizes
List of Posters
P1 – UNRAVELING THE MOLECULAR BASIS OF PEDIATRIC MYELODYSPLASTIC SYNDROME: INSIGHTS FROM CRISPR/CAS9-EDITED IPSCS BEARING THE SAMD9 P.I1567M MUTATION.
Joan Pera* Julio Castaño; Damia Romero-Moya; Oskar Marin-Bejar; Alessandra Giorgetti
*Barcelona, Spain
P2 – ARIANT PROFILING IN PEDIATRIC CHRONIC MYELOID LEUKEMIA
Yvonne Lisa Behrens; Gudrun Göhring; Laura Gaschler; Ronny Nienhold; Thea Reinkens; Elke Schirmer; Sabine Lukat; Sabine Knöß; Renate Strasser; Stephanie Sembill; Zofia Wotschofsky; Meinolf Suttorp; Manuela Krumbholz; Brigitte Schlegelberger; Markus Metzler; Axel Karow*
*Erlangen, Germany
P3 – SPECTRUM OF CLINICAL PHENOTYPES AND SOMATIC VARIANTS IN RUNX1-ASSOCIATED FAMILIAL PLATELET DISORDER WITH PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES
Alisa Förster*; Melanie Decker; Yvonne L. Behrens; Gudrun Göhring; Brigitte Schlegelberger; Tim Ripperger
*Hannover, Germany
P4 – PUMA-induced apoptosis drives bone marrow failure upon telomere shortening and leukemia in a mouse model of dyskeratosis congenita
Christian Molnar; Sheila Bohler*; Jovana Rajak; Julia Miriam Weiss; Irene Gonzalez-Mendez; Geoffroy Andrieux; Eva-Maria Demmerath; Madeleine Wahl; Lena Wendeburg; Gudrun Göhring; Brigitte Strahm; Doris Steinemann; Martina Rudelius; Melanie Börries; Leticia Quintanilla-Martinez; Charlotte M. Niemeyer; Verena Labi; Miriam Erlacher
*Freiburg, Germany
P5 – Association and interactions of the RIO kinases in the context of Diamond-Blackfan anemia
Hans-Dajo Von Wulffen*; Sheila Bohler; Corinna Spohr; Tilman Brummer; Pierre-Emmanuel Gleizes; Alexander Puzik; Charlotte Niemeyer; Miriam Erlacher
*Freiburg, Germany
P6 – NPM1 mutations in children with myelodysplastic syndrome with excess blasts
Ayami Yoshimi*; Miriam Erlacher; Peter Noellke; Senthilkumar Ramamoorthy; Gudrun Göhring; Shlomit Barzilai-Birenboim; Ivana Bodova; Jochen Buechner; Albert Catala; Valérie De Haas; Barbara De Moerloose; Michael Dworzak; Henrik Hasle; Kirsi Jahnukainen; Krisztian Kallay; Marko Kavcic; Paula Kjollerstrom; Franco Locatelli; Riccardo Masetti; Sophia Polychronopoulou; Markus Schmugge; Owen Smith; Jan Stary; Dominik Turkiewicz; Marek Ussowicz; Natalia Rotari; Marcin Wlodarski; Brigitte Strahm; Charlotte Niemeyer
*Freiburg, Germany
P7 – Identification of high-risk JMML by BMP4 bisulfite next-generation sequencing
Foued Ghanjati*; Annika Heck; Dirk Lebrecht; Peter Nöllke; Zoé Wehbe; Felicia Andresen; Natalia Rotari; Miriam Erlacher; European Working Group Of Myelodysplastic Syndromes In Childhood; Charlotte Niemeyer; Christian Flotho
*Freiburg, Germany
P8 – RIC vs MAC in allo-HSCT for Childhood Myelodysplastic Syndrome
Elena Morozova; Olesya Paina; Elena Semenova; Tatyana Gindina; Ludmila Zubarovskaya; Alexander Kulagin; Anna Osipova*; Tatiana Bykova
*Saint-Petersburg, Russia
P9 – Outcomes of hematopoietic stem cell transplantation in pediatric patients with myelodysplastic syndrome and acute myeloid leukemia secondary to inherited bone marrow failure syndromes
Laura Murillo-Sanjuán*; María Luz Uria-Oficialdegui; Gloria Hidalgo-Gómez; Laura Alonso García; Melissa Panesso Romero; María Isabel Benítez Carabante; Margarita Ortega Blanco; Cristina Díaz-De-Heredia
*Barcelona, Spain
P10 – Biology of bone marrow disorder characterize distinct subtypes of Refractory cytopenia of childhood (RCC)
Martina Sukova*; Ester Mejstrikova; Michaela Reiterova; Marketa Kubricanova-Zaliova; Eva Fronkova; Vit Campr; Zuzana Zemanova; Iveta Janotova; Lucie Sramkova; Jan Stary
* Prague, Czech Republic
P11 – PREVALENCE OF EXPOSURE TO SOCIO-ENVIRONMENTAL FACTORS IN MYELODYSPLASTIC SYNDROMES – A STUDY OF THE BRAZILIAN PEDIATRIC MYELODYSPLASTIC SYNDROME GROUP (GCB-SMD-PED)
Glaucia Regina Costa Murra*; Adeylson Guimarães Ribeiro; Marco Antônio De Oliveira; Lohana Karoline Macedo Pezente; Anita Frisanco De Oliveira; Rafael Balceiro; Maria Do Socorro Pombo De Oliveira; Mariana Tomazini Pinto; Luiz Fernando Lopes
*São Paulo, Brazil
P12 – A CASE OF KRAS-MUTATED JMML WITH HIGH METHYLATION PROFILE AND PERPLEXED CLINICAL COURSE.
Vasiliki Tzotzola*; Kondylia Antoniadi; Charikleia Kelaidi; Loizos Petrikkos; Elda Ioannidou; Evgenios Goussetis; Aikaterini Bountali; Kalliopi Manola; Elpidoforos Mantadakis; Kalliopi Stefanaki; Ioulia Peristeri; Charlotte Niemeyer; Sophia Polychronopoulou
* Athens, Greece
P13 – THE CLINICAL SPECTRUM AND BIOLOGICAL FINDINGS IN RAS-ASSOCIATED JUVENILE MYELOMONOCYTIC LEUKEMIA AND RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER
Hanne Verhulst; Laurens Van Camp; Mattias Hofmans*; Barbara De Moerloose
*Ghent, Belgium
P14 – Thirty years of Experience in the Treatment of Childhood Aplastic Anemia in Lithuania
Vilma Rutkauskaite*; Ramune Pasauliene; Goda Elizabeta Vaitkeviciene; Jelena Rascon
* Vilnius, Lithuania
P15 – Hospital admissions of aplastic anaemia: Real world evidence from UK children admitted from 2017 – 2022
Bamidele Famokunwa*; Morag Griffin; Aman Gupta; Stephen Thomas; Austin Kulasekararaj
*London, UK
P16 – REFRACTORY CYTOPENIA OF CHILDHOOD: CLINICAL FEATURES, PATHOLOGIC FINDINGS AND EXPERIENCE OF BRAZILIAN COOPERATIVE GROUP OF PEDIATRIC MYELODYSPLASTIC SYNDROME
Caroline Ramalho Rosa; Rafael Balceiro*; Aline Tansini; Thaís Regina Toledo De Santis; Gláucia Regina Costa Murra; Eduardo Caetano; Luiz Fernando Lopes; Anita Frisanco Oliveira
*São Paulo, Brazil
P17 – Recurrence of underlying congenital neutropenia without MDS after allogeneic stem cell transplantation in a patient with ELANE-mutated congenital neutropenia and secondary MDS
Ingrid Furlan*; Katharina Wustrau; Manfred Hoenig; Ayami Yoshimi; Ansgar Schulz
*Ulm, Germany
P18 – IMMUNOPHENOTYPE IN SAMD9/9L SYNDROME: CORRELATIONS WITH MORPHOLOGY
Charikleia Kelaidi*; Marianna Tzanoudaki; Loizos Petrikkos; Eleni Dana; Natalia Tourkantoni; Iordanis Pelagiadis; Kondylia Antoniadi; Eleni-Dikaia Ioannidou; Maria Kourti; Helen Kosmidis; Eftychia Stiakaki; Marina Oikonomou; Evgenios Goussetis; Ioulia Peristeri; Antonis Kattamis; Aikaterini Bountali; Kalliopi Manola; Kalliopi Stefanaki; Sophia Polychronopoulou1
*Athens, Greece
P19 – Telomere lenght and cytopenias: analysis of children referred to Brazilian Cooperative Group of Childhood Myelodysplastic Syndrome
Rafael Balceiro*; Anita Frisanco Oliveira; Luiz Fernando Lopes; Neysimelia Costa Villela; Marlene Pereira Garanito; Rodrigo Do Tocantins Calado De Saloma Rodrigues
*São Paulo, Brazil
P20 – CHILDHOOD MYELODYSPLASTIC NEOPLASM: GENETIC VARIANTS AND THEIR IMPACT ON DIAGNOSIS AND PROGNOSIS
Viviane Lovatel*; Eliane Rodrigues; Gerson Ferreira; Claudia Atayde; Rita De Cássia Tavares; Ana Paula Bueno; Eliana Abdelhay; Teresa Fernandez
* Rio de Janeiro, Brazil
P21 – Pitfalls in the diagnostics of SAA/RCC: Can whole exome sequencing lead us the way?
Wolfgang Novak*; Alexandra Frohne; Susanne Karlhuber; Raúl Jimenez-Heredia; Leo Kager; Michael Dworzak; Kaan Boztug
*Vienna, Austria
P22 – Identification of Functional Defects Leading to Bone Marrow Failure in GATA2 Deficiency
Charlotte Wantzen*; Baris Yigit; Yuan Suo; Roland Meisel; Shu Zang; Julia Miriam Weiss; Juncal Fernandez-Orth; Miriam Erlacher
*Freiburg, Germany
P23 – THERAPY-RELATED MYELODYSPLASTIC SYNDROMES (t-MDS) IN CHILDHOOD: THE EXPERIENCE OF THE HELLENIC STUDY GROUP FOR MDS/JMML/SAA, MEMBER OF THE EWOG-MDS/SAA WORKING GROUP
Loizos Petrikkos*; Marina Servitzoglou; Eleni Dana; Iordanis Pelagiadis; Charikleia Kelaidi; Kondilia Antoniadi; Eleni-Dikaia Ioannidou; Aikaterini Bountali; Kalliopi Manola; Kalliopi Stefanaki; Eftichia Stiakaki; Helen Kosmidis; Ioulia Peristeri; Margarita Baka; Sophia Polychronopoulou
*Athens, Greece
P24 – NATIONAL EXPERIENCE WITH IMMUNOSUPPRESSIVE THERAPY AND ELTROMBOPAG IN CHILDREN WITH APLASTIC ANEMIA- REAL WORLD DATA
Katarzyna Pawelec*; Katarzyna Machnik; Tomasz Ociepa; Jakub Musial; Joanna Bulsa; Marek Ussowicz
*Warsaw, Poland
P25 – The rare cases of co-occurrences of Down Syndrome Disease and Juvenile Myelomonocytic Leukemia
Barbara Buldini; Manuela Tumino; Elena Varotto; Samuela Francescato; Alberto Peloso; Annamaria Di Meglio; Anna Leszl; Maria Gabelli; Alice Cani; Riccardo Masetti; Alessandra Biffi; Laura Sainati; Silvia Bresolin*
*Bologna, Italy
P26 – Investigating and modulating leukemia initiating cells to reduce risk of post-transplant relapse in JMML
Hui Xiao*; Naile Koleci; Jun Wang; Jovana Rajak; Niels Anton Wehner; Sheila Bohler; Juncal Fernandez Orth; Charlotte M. Niemeyer; Miriam Erlacher
*Freiburg, Germany
P27 – MYELODYSPLASIA-RELATED CYTOGENETIC ABNORMALITES IN CHILDHOOD ACUTE MYELOID LEUKEMIA – A 20-YEAR I-BFM-AML COLLABORATIVE DATABASE STUDY
Kristian Juul Sandahl*; Kristian Løvvik Juul-Dam; Morten Krogh Herlin; Eigil Kjeldsen; Henrik Hasle
*Aarhus, Denmark
P28 – RELAPSED UBTF-TD MDS TREATED WITH VENETOCLAX AND AZACITIDINE
Henrik Hasle*; Marianne Ifversen; Katja Harder; Miriam Erlacher
*Aarhus, Denmark
P29 – Dyslipidemia after intensive immunosuppressive therapy versus hematopoietic stem cell transplantation in aplastic anemia: a single-center experience
C Holeczek; J Halter; C Arranto; S Schaedelin; R Mathew; A Leuppi-Taegtmeyer; T Burkard; M Betz; J Passweg; B Drexler*
*Basel, Switzerland
P30 – CLINICAL AND HEMATOLOGICAL PROFILE OF CHILDREN WITH CYTOPENIAS REFERRED TO THE BRAZILIAN COOPERATIVE GROUP OF PEDIATRIC MYELODYSPLASTIC SYNDROME
Caroline Ramalho Rosa; Rafael Balceiro*; Aline Tansini; Thaís Regina Toledo De Santis; Gláucia Regina Costa Murra; Eduardo Caetano; Luiz Fernando Lopes; Anita Frisanco Oliveira
*São Paulo, Brazil
P31 – Infant with SAMDL9 mutation, monosomy 7 and acute lymphoblastic leukemia
Ernest Bilic*; Toni Matic*; Maja Pavlovic*
*Zagreb, Croatia
P32 – Infant extramedullary KMT2A rearranged T/myeloid acute leukemia mimicking Langerhans cell histiocytosis
Barbora Vakrmanova*; Ester Mejstrikova; Jakub Jonas; Petr Pavlicek; Marketa Zaliova; Marek Turnovec; Livia Molcanyova; Eva Fronkova; Ondrej Hrusak; Lucie Sramkova
*Prague, Czech Republic
P33 – HScore calculation at diagnosis and during patient follow-up in two children with malignancy-associated hemophagocytic syndrome
Zühre Kaya*; Serap Kirkiz; Özge Vural; Ülker Koçak
*Ankara, Turkey
P34 – CAN A THIRD HAEMATOPOIETIC STEM CELL TRANSPLANTATION BE A VIABLE OPTION FOR JMML RELAPSE? A CASE REPORT
Francesca Vendemini*; Sonia Bonanomi; Marta Verna; Giorgio Ottaviano; Pietro Casartelli; Francesco Saettini; Adriana Balduzzi
*Monza, Italy
P35 – HEPATITIS-ASSOCIATED MYELODYSPLASTIC SYNDROME IN CHILDREN: REPORT OF 2 CASES
Francesco Pegoraro*; Irene Trambusti; Annalisa Tondo; Giuseppe Indolfi; Marinella Veltroni
*Florence, Italy
P36 – CASE REPORT: AN UNUSUAL CASE OF REFRACTORY CYTOPENIA OF CHILDHOOD IN A PATIENT WITH DOWN SYNDROME?
Viviany Viana*; Mn Nóbrega; Yc Souza; Ca Cambraia; Af Oliveira; R Balceiro
*Fortaleza, Brazil
P37 – JMML with NRAS mutation in ELANE associated severe congenital neutropenia
Hilde Hylland Uhlving*; Dorthe Grosen; Mathias Rathe; Mette Klarskov; Henrik Hasle; Tania Nicole Masmas
*Rigshospitalet, Denmark
P38 – Intensive chemotherapy as bridging to stem cell transplantation in 5 year old girl with juvenile myelomonocytic leukemia– case report
Bartosz Chyżyński*; Katarzyna Pawelec; Marek Ussowicz; Paweł Łaguna
*Warsaw, Poland
P39 – NATURAL HISTORY OF RALD: A 20 YEAR FOLLOW-UP OF A NRAS MUTATED PATIENT EXCLUDING A MALIGNANT PROGRESSION
Enrico Attardi*; Beatrice Rivalta; Cristina Cifaldi; Vittorio Rosti; Lucia Pacillo; Hajro Hajrullaj; Silvia Di Cesare; Matteo Luciani; Federica Barzaghi; Andrea Finocchi; Gigliola Di Matteo; Alessandro Aiuti; Franco Locatelli; Maria Teresa Voso; Giuseppe Palumbo; Caterina Cancrini
*Rome, Italy
P40 – Epidemiological Analysis of Constitutional and Acquired Aplastic Anemia in Latvia: 1998-2022
Iveta Racko*; Zanna Kovalova
*Riga, Latvia
P41 – IMMUNOSUPPRESSIVE THERAPY IN A PATIENT WITH SAA-like RCC AND GATA2 DEFICIENCY
D Kroiss*; W Novak; S Karlhuber; G Engstler; H Boztug; M Dworzak
*Vienna, Austria
P42 – GATA2 DEFICIENCY SYNDROME: MDS / ACUTE MYELOID LEUKEMIA IN AN ADOLESCENT PATIENT
Şebnem Yılmaz; Özlem Tüfekçi; Hale Ören*
*Izmir, Turkey
P43 – Peripheral and bone marrow G-CSF-related myeloblasts rate in a patient with severe congenital neutropenia
Irene Trambusti*; Francesco Pegoraro; Marco Tellini; Annalisa Tondo; Marinella Veltroni
*Florence, Italy
P44 – ALLOGENEIC STEM CELL TRANSPLANTATION FOR MYELODYSPLASTIC SYNDROME COMPLICATED BY SYNCHRONOUS ACUTE GRAFT-VS-HOST DISEASE AND CYTOMEGALOVIRUS INFECTION
Ana Fraga; Rita Aldeia Da Silva*; Filipa Leite; Ana Maia Ferreira; Gil Brás; Iris Maia
*Porto, Portugal
P45 – DIAGNOSIS OF JUVENILE MYELOMONOCYTIC LEUKEMIA, IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1 – CASE REPORT
Rita Aldeia Da Silva*; Ana Fraga; Filipa Leite; João Silva; Maria João Gil-Da-Costa; Iris Maia
*Porto, Portugal
P46 – Juvenile Myelomonocytic Leukemia with telomere shortening: case report
Anita Frisanco Oliveira*; Rafael Balceiro; Neysimelia Costa Villela; Luiz Fernando Lopes
*São Paulo, Brazil
Conference Time
The Meeting will officially run on Western European Summer Time – WEST, UTC+1